Basic Human Neuroanatomy
A Clinically Oriented Atlas 
Case 26 Answers
1.  This patient's signs and symptoms constitute a classical neurologic syndrome.  What is the name of that syndrome?
 
Parkinson Disease

2.  What is the anatomical location of the basic pathologic process leading to this patient's condition?  What anatomical pathway(s) is involved in this patient's condition?
 
Substantia nigra (pars compacta).  Nigrostriatal fibers

3.  What neurotransmitter systems are involved in the manifestations of this syndrome, and which manifestations are associated with which neurotransmitters?

Decreased dopamine leads to Parkinsonian Sx.  Of course, other neurotransmitters and other parts of the basal nuclei connections are also involved in producing the signs and symptoms of Parkinson disease.

4.  In general, what type of pathologic process is involved in this syndrome?
 
Degenerative

5.  What diagnostic procedure(s) would you undertake at this point?


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