Case History #177
Date of Consultation: 12-19-1989
HISTORY OF PRESENT ILLNESS:
This 31-year-old right-handed white female bus driver was referred for
neurologic evaluation of her headache problem and visual
symptoms. Her difficulty with headaches began approximately two
years prior to consultation (1987), and she knows of no specific
circumstances surrounding the onset of the problem. The frequency
of her headaches varies between one to four headaches per week.
There are no well-defined neurologic signs or symptoms occurring either
before, during, or in between headache attacks, although she does
experience bilateral blurred vision during an attack. Her
headaches are usually bilateral and located in the retro-orbital and
supraorbital regions. She describes the pain as a steady, aching,
pressure-like sensation. The headaches generally last
approximately two hours. Symptoms associated with the headaches
include nausea, photophobia, and a desire to lie quietly in a dark
room. They are often triggered by her menstrual periods, exposure
to heat, and stress.
In addition to her headaches, the patient was recently discovered to
have optic disc atrophy and visual field defects in the right eye on a
routine eye examination. She was not aware of any visual symptoms
prior to this examination.
Aside from the above, the patient denied any other neurologic or
systemic signs and symptoms. Her past history reveals a 15
pack-year history of smoking and a previous rear-end motor vehicle
accident a number of years ago without any sequelae.
NEUROLOGICAL EXAMINATION:
Mental Status Exam: Intact.
Cranial Nerves: Sensation of
smell was intact bilaterally. Visual acuity was J2 in the right
eye and J1 in the left eye without glasses. Funduscopic
examination revealed optic atrophy of the right optic disc and a normal
left optic disc. Visual fields by confrontation were
unremarkable. An afferent pupillary defect was present in the
right eye, as well as 25 per cent color desaturation on the
right. External ocular movements were full without nystagmus or
diplopia. The right pupil was 5 mm, and the left pupil was 6 mm
with normal reactivity, except for the relative afferent pupillary
defect in the right eye. There was no ptosis present.
Sensory and motor functions of the Vth cranial nerve were normal.
There was no facial weakness. Hearing was intact in the left ear
but was diminished in the right ear. XIth cranial nerve functions
were normal. Tongue and palate appeared normal.
Motor System: Intact.
Reflexes:
Intact.
Sensory System: Intact.
Cerebellar Function: Intact.
Gait and Stance: Intact.
Questions
1. Where in the visual pathway would you localize the lesion in
this case (optic nerve, optic chiasma, optic tract, optic radiations,
or occipital cortex)?
2. What is an afferent pupillary defect (Marcus Gunn pupil), what
is its anatomical basis, and what localizing significance does it
have?
3. What side of the nervous system is involved in this
case? What specific structure(s) is involved by the pathologic
process?
4. In general, what type of pathologic process is involved in
this case?
5. Are the visual findings and the patient’s headache
problem related in this case?
6. How would you classify the patient’s headache
problem?
7. What diagnostic procedure(s) would you undertake at this point?